ADDRESS:
	Department of Zoology, Room 3340 (map)
	University of British Columbia
	6270 University Blvd.
	Vancouver BC V6T 1Z4, Canada
	FAX:  (604) 822-2416
	Phone: (604) 822-2778
	Email: otto at zoology.ubc.ca

A Sample of Seminars:

SARS-CoV-2: An evolving pandemic (Society for the Study of Evolution, Evolution in Action Symposium, Cleveland OH, 2022) [PowerPoint]

Linking levels of selection with genetic modifiers (Society for the Study of Evolution, Presidential Address, Portland OR, 2017)

The population genetics of sex and recombination (Genetics Society Annual Meeting, Warwick UK, 2001)

What factors limit the rate of evolution? (Peter Wall Institute of Advanced Studies, UBC, 1999)

The debate over dominance (History and Memory seminar, Green College, UBC, 1998)

Rates of evolution in changing environments (Evolution meetings, 1997)

Evolution with three sexes: The case of Eulimnadia texana (seminar in Honours Biology 347, UBC, 1997)

Evolution of recombination (seminar in the Institute of Applied Mathematics, UBC, September 30 1996)

The evolution of recombination: Removing the limits to natural selection (CalPEG, 1996)

Programs:

Using the notation of Kirkpatrick et al. (2002) in Mathematica, by Rich FitzJohn.

Model of X-Inactivation in Human Blood Cells, by Jordana Tzenova. (Download pascal file or executable file for Windows)

Supplementary Material and Proofs:

Otto, S. P., J. R. Pannell, C. L. Peichel, T.-L. Ashman, D. Charlesworth, A. K. Chippindale, L. F. Delph, R. F. Guerrero, S. V. Scarpino, B. F. McAllister (2011) About PAR: The distinct evolutionary dynamics of the pseudoautosomal region. Trends in Genetics, 27:358-367.

→ A Mathematica 6.0 file deriving allele frequency between the X and Y at PAR genes when selection is overdominant with identical fitnesses in males and females.

→ A Mathematica 6.0 file to derive the fixation probability of a deleterious allele sweeping along with a beneficial mutation.

→ A Mathematica 6.0 file to perform the equilibrium and stability analyses.

Otto, S. P., M. R. Servedio, S. L. Nuismer (2008) Frequency-dependent selection and the evolution of assortative mating. Genetics, 179: 2091-2112.

→ A Mathematica 5.2 file or Mathematica 8.0 file to perform the QLE analyses predicting when assortative mating would evolve.

→ A Mathematica 5.2 file or Mathematica 8.0 file to perform the stability analyses predicting when assortative mating would evolve (Appendix C).

Otto, S. P. and C. D. Jones (2000) Detecting the undetected: Estimating the total number of loci underlying a trait in QTL analyses. Genetics,156: 2093-2107.

→ A Mathematica 3.0 file (via ftp) to estimate the number of loci underlying a phenotypic trait difference using data generated from a QTL study.

Phillips, P. C., S. P. Otto, and M. C. Whitlock (1999) Beyond the average: The evolutionary importance of epistasis and the variability of epistatic effects. In Epistasis and the Evolutionary Process, eds. J. Wolf, E. D. Brodie III, and M. J. Wade.

→ Proof of the appendix in html format or in Mathematica 3.0 format (via ftp).

Otto, S. P. and M. W. Feldman (1997) Deleterious mutations, variable epistatic interactions and the evolution of recombination. Theoretical Population Biology, 51:134-147.

→ A Mathematica file that outlines the local stability analysis.