Linda Matsuuchi

Full Professor
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  • Research area
    Cell and Developmental Biology
  • Lab members
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  • History

    A.B., Barnard College; M.A., M.Phil, Ph.D. Columbia University (New York City); Postdoctoral Fellow, University of California Berkeley (1981-1985); Assistant Research Biochemist, University of California San Francisco (1985-1991); UBC since 1992; Member of the Graduate Program in Cell and Developmental Biology; Associate Director of the Life Sciences Institute (2008-2013)

My lab is interested in understanding the cell signaling of specific membrane receptors, combining aspects of Cell Biology, Immunology , Biochemistry and Molecular Biology.Structure and function of the antigen receptor on B lymphocytes: The B cell receptor is composed of membrane immunoglobulin M (mIgM) and a heterodimer of two associated proteins, Ig-alpha and Ig- beta. When the receptor is on the cell surface of B lymphocytes it functions to transmit intracellular signals that regulate cell growth and differentiation and it binds to antigen for the generation of the immune response. We are studying the downstream consequences of intracellular signaling and how the BCR interacts with protein tyrosine kinases, phosphatases and other associated proteins. In addition we are exploring how signaling changes the cytoskeletal architecture in B lymphocytes. Recently my lab has embarked on a study of the gap junction protein connexin43 (Cx43), whose expression profoundly influences lymphocyte responses to BCR and chemokine receptor signalling, in particular regulating rearrangements in the actin cytoskeleton.

Lab members:

May Dang Lawson (Lab Manager) and Kate Choi (Tech 3)-both joint with M. Gold

Farnaz Pournia (PhD student); Victor Mo (MSc student)

Past Lab members (Graduate students, Postdocs and Staff): Dr. Marcia McCoy Graves (joint with M.Gold and C. Roskelley), Letitia Falk Biagi, Steve Machtaler, Caren Jang Grande, Janis Dylke, Teresa Jackson, Lorna Santos, Colm Condon, Sharon Hourihane, Lori Joyce, Jessica Escribano, Shaun Foy

Past Lab members (Independent study students and Work Learn students): Connor Keane, Michael Hall, Henry Lu, Matthew Lowe, Caroline Chu, Kate Choi, Gabe Woolam, Colm Condon, Tally Vertinsky, Cathy Brown, Karen Chua (Ung), Corey Ming-Lum, Aneez Mohammed, Katherine Tung, Shaun Foy

CSI Investigator Award

For Research

Faculty of Science Achievement Award

For Service
Mutations of Cx43 that affect B cell spreading in response to BCR signalling
Biology Open 3: 185-194
Falk, L., M. Dang-Lawson, J.L. Vega, F. Pournia, K. Choi, C. Jang, C.C. Naus, L. Matsuuchi
The role of the gap junction protein connexin43 in B lymphocyte motility and migration
FEBS Letters 588: 1249-1258
Machtaler, S., K. Choi, M. Dang-Lawson, L. Falk, F. Pournia, C.C. Naus, L. Matsuuchi
Gap junction proteins on the move: Connexins, the cytoskeleton and migration
Biochimica et Biophysica Acta 1828: 94-108
Matsuuchi, L. and C.C. Naus
The Gap junction protein Connexin43 regulates B-lymphocyte spreading and adhesion
Journal of Cell Science 124: 2611-2621
Machtaler, S., Dang-Lawson, M., Choi, K., Jang, C., Naus, C.C. and L. Matsuuchi
The role of Ig-α and Ig-β in B cell antigen receptor internalization
Immunology Letters 134: 75-82
Jang, C., Machtaler, S. and L. Matsuuchi
Engineered cell surface expression of membrane immunoglobulin as a means to identify monoclonal antibody-secreting hybridomas
J. Immunol. Methods 343: 28-41
Price, PW, McKinney, EC, Wang, Y, Sasser, LE, Kandasamy, MK, Matsuuchi, L, Milcarek, C, Deal, Meagher, RB
Role of the extracellular and transmembrane domains of Ig-α/β in assembly of the B cell antigen receptor
Immunology Letters 112: 47 – 57
Dylke, J., Lopes, J., Dang-Lawson, M., Machtaler, S. and Matsuuchi, L
Localization of the Ig α/β component of the BCR in membrane microdomains in a B lymphoma variant
Immunology Letters 99: 69-79
Jackson, T.L., Santos, L., Dang-Lawson, M. and Matsuuchi, L
Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor
PNAS 101: 1027-1032
Wang, L.D., Lopes, J., Cooper, A.B., Dang-Lawson, M., Matsuuchi, L. and M.R. Clark
Association of chains of the B cell antigen receptor with multiple proteinchaperones
Immunology Letters. 78: 149-160
Foy, S.P. and Matsuuchi, L