What We've Done

Natural Competence
Published Research
Reviews and Book Chapters
Methods
Research in Other Areas
The Hotspot Paradox
Protist Evolution
Quorum Sensing
Evolution of Sex
Pedagogy

Ongoing research on natural competence:

In press:

None at present

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Published research:
Maughan H, Wilson La and Redfield RJ. 2010. Bacterial DNA Uptake Sequences Can Accumulate by Molecular Drive Alone. Genetics. doi:10.1534/genetics.110.119438  PDF
Redfield R. 2009. Looking to bacteria for clues. Science. 325(5943): 946 PDF
Sinha S, Bosse J, Schippers T, Kroll JS, Redfield R and Langford P. 2009. Natural competence in strains of Actinobacillus pleuropneumoniae. FEMS Microbiology Letters. 298(1): 124-30 PDF
Sinha S, Cameron AD, Redfield RJ. 2009. Sxy induces a CRP-S regulon in Escherichia coli. Journal of Bacteriology. 191(6): 5180-95 PDF  Supplementary material
Maughan H, Redfield RJ. 2009. Extensive variation in natural competence in Haemophilus influenzae. Evolution. 63(7): 1852-66 PDF
Findlay WA, Redfield RJ. 2009. Coevolution of DNA Uptake Sequences and Bacterial Proteomes. Genome. Biol Evol. 5(1):45-55. PDF
Maughan H, Redfield RJ. 2009. Tracing the evolution of competence in Haemophilus influenzae. PLoS One 4(6):e5854. PDF
Cameron AD, Redfield RJ. 2008. CRP binding and transcription activation at CRP-S sites. Journal of Molecular Biology 383(2):313-23. PDF
Cameron AD, Volar M, Bannister LA, Redfield RJ. 2008. RNA secondary structure regulates the translation of sxy and competence development in Haemophilus influenzae. Nucleic Acids Research 36(1):10-20.  PDF
Cameron, A. D. S., and Redfield, R. J. 2006. Non-canonical CRP sites control competence regulons in Escherichia coli and many other gamma-proteobacteria. Nucleic Acids Research 36(1) : 10-20. PDF Supplementary tables
Redfield, R. J., Findlay, W. A., Bossé, J., Kroll, J. S, Cameron, A. D. S. and Nash, J. H. E. 2006. Evolution of competence and DNA uptake specificity in the Pasteurellaceae. BMC Evolutionary Biology 6:82. PDF
Redfield, R. J., Cameron A. D, Qian, Q., Hinds, J., Ali, T. R., Kroll, J. S. and Langford, P. 2004. A novel CRP-dependent regulon controls expression of competence genes in Haemophilus influenzae. 2005. Journal of Molecular Biology 347: 735-747. PDF
Bakkali, M., Chen, T.-Y., Lee, H.-C. and Redfield, R. J. 2004 Evolutionary stability of DNA uptake sequences in the Pasteurellaceae.
Proceedings of the National Academy of Sciences, USA 101: 4513-4518. PDF
Wang, Y., Goodman, S., Redfield, R. J. and Chen, C. 2002 Natural transformation and DNA uptake signal sequences in Actinobacillus actinomycetemcomitans. Journal of Bacteriology 184: 3442-3449. PDF
MacFadyen, L. P., Chen, D., Vo, H. C., Liao, D., Sinotte, R., and Redfield, R. J. 2001. Competence development by Haemophilus influenzae is regulated by the availability of nucleic acid precursors. Molecular Microbiology 40: 700-7. PDF
Ma, C., and Redfield, R. J. 2000 Point mutations in a peptidoglycan biosynthesis gene cause competence induction in Haemophilus influenzae.
Journal of Bacteriology 182:3323-3330. PDF
Macfadyen, L. P., C. Ma and R. J. Redfield. 1998. A 3':5'-cAMP phosphodiesterase modulates cAMP levels and optimizes competence in H. influenzae Rd. Journal of Bacteriology 180: 44-1-4405. PDF
Macfadyen, L. P. Regulation of competence development in Haemophilus influenzae. (2000) Journal of Theoretical Biology 207: 349-59. PDF
Redfield, R. J., M. R. Schrag, and A. M. Dean. 1997. The evolution of bacterial transformation: sex with poor relations. Genetics 146:27-38. PDF
Macfadyen, L. P., I. Dorocicz, J. Reizer, M. H. Saier Jr., and R. J. Redfield. 1996. Regulation of competence development and sugar utilization in Haemophilus influenzae Rd by a phosphoenolpyruvate:fructose phosphotransferase system. Molecular Microbiology 21 (5):941-952. PDF
Macfadyen, L. P., and R. J. Redfield, 1996. Life in Mucus: Sugar metabolism in Haemophilus influenzae. Research in Microbiology 147: 541-551 (this paper is an invited contribution to a single-topic issue). PDF
Redfield, R. J. 1993. Evolution of natural transformation: Testing the DNA repair hypothesis in Haemophilus influenzae and Bacillus subtilis. Genetics 133:755-761. PDF
Williams, P., L. Bannister, and R. J. Redfield. 1994 The Haemophilus influenzae sxy-1 mutation is in a newly identified gene essential for competence.
Journal of Bacteriology 176 (22) 6789-6794. PDF
Dorocicz, I., P. Williams, and R. J. Redfield. 1993. The Haemophilus influenzae adenylate cyclase gene: cloning, sequence, and essential role in competence.
Journal of Bacteriology 175:7142-49. PDF
Redfield, R. J., 1993. Genes for breakfast: the have-your-cake-and-eat-it-too of natural transformation. J. Hered. 84: 400-404 (Proceedings of AGA Symposium, 1992).
Redfield, R. J. 1991. sxy-1, a Haemophilus influenzae mutation causing greatly enhanced spontaneous competence.
Journal of Bacteriology 173: 5612-5618. PDF
Redfield, R. J. 1991. Bacterial mating preferences. Nature 352: 25-26.
Tomb, J.-F., G. Barcak, M. Chandler, R. J. Redfield and H. O. Smith, 1989. Transposon mutagenesis, characterization, and cloning of transformation genes of Haemophilus influenzae Rd.
Journal of Bacteriology 171: 3796-3802. PDF
Lee, J. J., H. O. Smith and R. J. Redfield, 1989. Organization of the Haemophilus influenzae Rd genome.
Journal of Bacteriology 171: 3016-3024. PDF
Redfield, R. J., 1988. Evolution of bacterial transformation: is sex with dead cells ever better than no sex at all? Genetics 119: 213-221. PDF

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Reviews and Book Chapters:

Maughan H, Sinha S, Wilson L, Redfield R (2008). Competence, DNA Uptake and Transformation in the Pasteurellaceae. Chapter in Pasteurellaceae: Biology, Genomics and Molecular Aspects, Caister Academic Press, ISBN: 978-1-904455-34-9. PDF
Redfield, R. J. 2001. Do bacteria have sex? Nature Reviews Genetics 2:634-9. PDF
Redfield, R. J. 2001 Transformation. Encyclopedia of Genetics, Academic Press.
Redfield, R. J. 2001 Transformation and Transfection. Two entries in the Encyclopedia of Genetics, Academic Press. PDF
Redfield, R. J. 2002 Haemophilus influenzae, Genetics. Entry in Encyclopedia of Microbiology, Academic Press.
Redfield, R. J. 1997. The problem of the evolution of sex. Proceedings of a NASA Life Sciences Workshop on Evolution: a molecular perspective. Woods Hole, October 1997.
Redfield, R. J. A truly pluralistic view of sex and recombination. 1999 Journal of Evolutionary Biology 12: 1043-1046 PDF
Redfield, R. J. 1996. The Haemophilus influenzae genome: after sequencing, then what? MedScape/Women's Health , June 1996 (a peer-reviewed on-line journal, available at http://www.medscape.com). Mooers 1996.

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Methods:
Poje, G. and Redfield, R. J. 2002. General Methods for culturing Haemophilus influenzae, and Transformation of Haemophilus influenzae. Two chapters in Molecular Methods for Haemophilus influenzae:, M. Herbert, Editor, Humana Press. Growth PDF, Transformation PDF
Williams, P., W. L. Hung, and R. J. Redfield. 1996. Cell transfer by filtration: evaluation of protocols for transformational competence. FEMS (Federation of European Microbiology Societies) Microbiology Letters 137:183-187.

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Research in Other Areas:

The Hotspot Paradox:
Pineda-Krch, M., and Redfield, R. J. 2005. Persistence and loss of meiotic recombination hotspots. Genetics 169:2913-2928. PDF
Boulton, A., R. Myers and R. J. Redfield. 1997. The hotspot conversion paradox and the evolution of meiotic recombination. Proceedings of the National Academy of Sciences, USA 94:8058-8063. PDF

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Protist Evolution:
Dacks, J. B., Silberman, J. D., Simpson, A. G., Moriya, S., Kudo, T., Ohkuma, M. and Redfield, R. J. 2001. Oxymonads are closely related to the excavate taxon Trimastix. Molecular Biology and Evolution 18:1034-44. PDF
Dacks, J. B. and R. J. Redfield. Phylogenetic placement of Trichonympha. Journal of Eukaryotic Microbiology 45: 445-447.

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Quorum Sensing:
Redfield, R. J. 2002. Is quorum sensing a side effect of diffusion sensing? Trends in Microbiology 10:365-370. PDF

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Evolution of Sex:
Redfield, R. J. 1994. Male mutation rates and the cost of sex for females. Nature 369: 145-147. PDF

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Pedagogy:
Redfield, R., J. Mayer-Smith and A. Griffiths. 1997, Stuck on the Web. Genetics Society of Canada Bulletin. 28(1): 23.
Yazon, J., Mayer-Smith, J. A., and Redfield, R. J. 2002. Does the medium change the message? The impact of a web-based genetics course on university students’ perspectives on learning and teaching. Computers and Education 38: 267-285.

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