Otto & Feldman 1997

Deleterious mutations, variable epistatic interactions and the Evolution of Recombination (1997) Otto, S. P. and M. W. Feldman. Theoretical Population Biology, 51:134-147.

This paper examines the evolution of recombination in response to deleterious mutations. It builds upon previous work by examining whether variability in the ways in which loci interact has an influence on when recombination is favored.

Most previous models have assumed that all loci interact equivalently. Yet genetic loci tend to interact in a variety of ways, some strongly, others weakly, some synergistically, others antagonistically. This variability makes it harder for high rates of recombination to evolve.

You may obtain via ftp a dvi version (without figures) or a postscript version (with figures) of this paper. In addition, there is a Mathematica file that outlines the local stability analysis.

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