Study Questions for Final

In this problem, we will look at the degree of somatic mosaicism that is expected to occur in a multicellular organism.

Consider the genotype of the developing individual. When the zygote is first formed, it has its original genotype (call this the non-mutant). Every cell division, there is a chance that a mutation will occur. Ignore back-mutations.

Write down the frequency of non-mutant and mutant cells as a function of the number of cell divisions since zygote formation, t.

In an organism that undergoes 100 cell divisions during development, what fraction of the cells will be mutant at a particular gene at the end of development if equals 10-7 per cell division?

Across an entire genome of 105 genes, would be approximately 10-2 per cell division. What fraction of cells in the adult will carry a mutant gene somewhere in the genome?