PhD student in the graduate program in Experimental Medicine
Projects:
- Isolation and Characterization of Stem Cells from the Olfactory Neuroepithelium.
- Development of Models for the In Vivo Transplanation of Neuroepithelial Stem /Progenitor Cells.

My research interests lie within the field of stem cell biology. The Roskams’ lab has previously identified novel neural progenitors from the OE capable of forming clonally derived adherent colonies that can be expanded and differentiate into neurons and glia. My current studies focus on the isolation and purification of novel putative stem cell populations using stem cell traits, such as the ability to efflux toxic dye, thus displaying the Hoechst negative side population (Sp), or the ability to form aggregates of neural stem cells in suspension, termed neurospheres, and compare these to our lab’s previously isolated progenitors. Isolation and enrichment of such populations will allow me to define serum free ex vivo culture conditions required for the maintenance and expansion of olfactory epithelial stem cells by examining their receptor expression profiles and utilizing various protein molecules, such as Notch ligands, or factors secreted by olfactory epithelial glial cells (Yo! Check out Edmund Au for these factors-stayed tuned!).
These studies will allow us to characterize the regulatory mechanisms involved in neuroregeneration of the olfactory epithelium and lead to the assessment of these cells/molecules in an in vivo setting. Ultimately, these results may lead to approaches to improve treatment of CNS neurodegeneration following stroke or trauma and serve to enhance the quality of life for those managing related disabilities.
Supported by: The Heart and Stroke Foundation of Canada and the Michael Smith Foundation for Health Research

Contact Barb at: bmurdoch@zoology.ubc.ca