The UBC Caenorhabditis
elegans Gene Knockout Laboratory is part of an international
consortium, working to produce null mutations in all identified
and predicted genes in the C. elegans genome.
et al. 2002
Improved detection of small deletions in complex pools
of DNA. Nucleic Acids Research 30: e52.
et al. 2007
Efficient high-resolution deletion discovery in Caenorhabditis
elegans using oligonucleotide by Array Comparative Genomic Hybridization.
Genome Research 2007 Mar;17(3):337-47
and Moerman. 2006
C. elegans deletion mutant screening.
Methods Mol. Biol. 2006;351:51-8.
Research - The goal of our muscle research lab is to
investigate the assembly and organization of myofilaments within
the body wall muscle of C. elegans.
Myoblast Migration Project - In an effort to
identify the proteins involved in early myoblast migrations we
are currently testing genes predicted to be in, or interacting
with the ECM using RNAi knockdowns.
et al. 2002
C. elegans PAT-4/ILK functions as an adaptor
protein to mediate interactions within integrin adhesion complexes.
Current Biology 12:1-20. [This paper was the subject
of a dispatch in Current Biology]
and Williams 2006
Sarcomere assembly in C. elegans muscle. WormBook
et al. 2000
UNC-112: a new protein required for myofilament initiation and
organization in C. elegans. J. Cell Biol. 150: 253-264.
[This paper was the subject of a review in JCB]
objective of the project was to define the RNA expression profiles
in specific tissues and cells, and developmental stages of C.
objective was the development of a protein expression baseline
for specific tissues during development.
Hunt-Newbury, et al. 2007
High-throughput in vivo analysis of gene expression in Caenorhabitis
elegans. PLoS Biol. 5(9): e237
et al. 2005
Functional genomics of the Cilium, a sensory organelle.
Current Biology 15:1-7.
et al. 2006
The ELT-2 GATA-factor and the global regulation of transcription
in the C. elegans intestine. Dev Biol. Oct 21;
[Epub ahead of print]