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The UBC Caenorhabditis elegans Gene Knockout Laboratory is part of an international consortium, working to produce null mutations in all identified and predicted genes in the C. elegans genome.

Featured Publications :

Edgley et al. 2002
Improved detection of small deletions in complex pools of DNA. Nucleic Acids Research 30: e52.

Maydan et al. 2007
Efficient high-resolution deletion discovery in Caenorhabditis elegans using oligonucleotide by Array Comparative Genomic Hybridization. Genome Research 2007 Mar;17(3):337-47

Barstead and Moerman. 2006
C. elegans deletion mutant screening. Methods Mol. Biol. 2006;351:51-8.

Myofilament Research - The goal of our muscle research lab is to investigate the assembly and organization of myofilaments within the body wall muscle of C. elegans.

Myoblast Migration Project - In an effort to identify the proteins involved in early myoblast migrations we are currently testing genes predicted to be in, or interacting with the ECM using RNAi knockdowns.

Featured Publications :

Mackinnon et al. 2002
C. elegans PAT-4/ILK functions as an adaptor protein to mediate interactions within integrin adhesion complexes. Current Biology 12:1-20. [This paper was the subject of a dispatch in Current Biology]

Moerman and Williams 2006
Sarcomere assembly in C. elegans muscle. WormBook

Rogalski et al. 2000
UNC-112: a new protein required for myofilament initiation and organization in C. elegans. J. Cell Biol. 150: 253-264. [This paper was the subject of a review in JCB]

An objective of the project was to define the RNA expression profiles in specific tissues and cells, and developmental stages of C. elegans. Another objective was the development of a protein expression baseline for specific tissues during development.

Featured Publications:

HOT Publication!
Hunt-Newbury, et al. 2007
High-throughput in vivo analysis of gene expression in Caenorhabitis elegans. PLoS Biol. 5(9): e237

Blacque et al. 2005
Functional genomics of the Cilium, a sensory organelle. Current Biology 15:1-7.

McGhee et al. 2006
The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine. Dev Biol. Oct 21; [Epub ahead of print]



 Moerman Laboratory
2440 - Life Sciences Centre
2350 Health Sciences Mall
University of British Columbia
Vancouver, BC
Canada V6T 1Z3