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Publications

  1. Jefferies, W.A., G. Kolaitis & R 1993.. The Interferon-gamma induced recognition of the antigen processing variant CMT.64 by cytolytic T cells can be replaced by sequential addition of B2-microglobulin and antigenic peptides. J. Immunol
  2. Matsuse, T., S. Hayashi, H. Keunnecke, W.A. Jefferies & J.C. Hogg 1992. The Adenoviral early glycoprotein E1a but not the E3/19k gene is amplified in frozen lung tissue from patients with Chronic Obstructive Pulmonary Syndrome. J. Am. Physiol. 146: 177-184
  3. Lippe, R., E. Luke, Y.T. Kuah, C. Lomas & W.A. Jefferies 1991. Adenovirus infection inhibits the phosphorylation of major histocompatibility complex class I proteins. J. Exp. Med. 174: 1159-1166
  4. Lippe, R., G. Kolaitis, C. Michaelis, F. Tufaro & W.A. Jefferies 1991. Distinguishing between the requirements for viral versus allogeneic cytotoxic T cell recognition. J. Immunol. 150: 3170-3179
  5. Jefferies, W.A. & H.G. Burgert 1990. E3 link from adenovirus 2 is an immunosubversive protein that binds to a structural motif regulating the intracellular transport of major histocompatibility complex class I proteins. J. Exp. Med. 172: 1653-1664

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Wilfred A. Jefferies

Associate Member

Email:
Research area: Cell and Developmental Biology
History: B.Sc., Victoria (B.C.); D. Phil., Oxford; Royal Society of London Fellow; Wellcome Trust Fellow; Lady Tata Memorial Fellow; Institut Suissede Recherches Experimentales sur le Cancer, Switzerland (1985-1987); MRC of Canada Fellow; Ludwig Institute for Cancer Research Karolinska Institute, Stockholm, Sweden (1987-1989)



Six areas of cell biology research being pursued in Dr. Jefferies' group.

i) Localizing by molecular biological techniques the segments of MHC Class I proteins which control their rate of intracellular assembly and transport. The cloning of transport and assembly proteins.

ii) Characterizing the association between the immunosubversive E3/19K proteins of Adenovirus-2 and MHC Class I proteins in human and murine systems.

iii) Examining the ability of recombinant MHC Class I proteins to act as restriction elements for cytolytic T lymphocytes in Influenzae A virus infected transgenic mice.

iv) Determining the intracellular pathways for processing and presentation of foreign antigens in MHC Class I and Class II restricted responses.

v) Determining the molecular basis of cyclo-sporin A immunosuppression.

vi) Novel iron transport molecules in humans.

Last updated 2 January 2008