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People

Publications

  1. Duncan GJ, Assinck P, Hilton BJ 2014. Canonical Wnt signalling in PDGFRalpha-expressing cells is a critical regulator of astrogliosis and axon regeneration following CNS injury. The Journal of neuroscience : the official journal of the Society for Neuroscience 34:16163-16165
  2. Hilton BJ, Assinck P, Duncan GJ, Lu D, Lo S, Tetzlaff W 2013. Dorsolateral funiculus lesioning of the mouse cervical spinal cord at C4 but not at C6 results in sustained forelimb motor deficits. Journal of neurotrauma 30:1070-1083
  3. Plemel, J R, Chojnacki, A., Sparling, J. S., Liu, J., Plunet, W., Duncan, G. J., Park, S. E., et al (2011). Platelet-Derived Growth Factor-Responsive Neural Precursors Give Rise to Myelinating Oligodendrocytes After Transplantation into the Spinal Cords of Contused Rats and Dysmyelinated Mice. Glia, 59(12), 1891–1910.
  4. Plemel, Jason R, Duncan, G., Chen, K.-W. K., Shannon, C., Park, S., Sparling, J. S., & Tetzlaff, W (2008). A graded forceps crush spinal cord injury model in mice. Journal of neurotrauma, 25(4), 350–70.
  5. Plemel JR, Keough MB, Duncan GJ, Sparling JS, Yong VW, Stys PK, Tetzlaff W . Remyelination after spinal cord injury: is it a target for repair?. Progress in neurobiology 117:54-72

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Greg Duncan

PhD Student

Email:
Research area: Cell and Developmental Biology
Supervisor: W. Tetzlaff
History: B.Sc Cell Biology and Genetics, University of British Columbia

Myelin is proteolipid that ensheathes the long processes of neurons (termed axons) which carry information to and from the brain. It greatly enhances the speed of conduction and reduces the energy use within the axon. Diseases like periventricular leukomalacia in infants, multiple sclerosis (MS) in adults or simply traumatic injury can damage myelin. Regeneration of myelin occurs in most MS patients, but is often incomplete. A failure to regenerate myelin is associated with increased axon loss, the main correlate of progressive disability in MS patients.

Previously, I determined that myelin regulatory factor (myrf), an essential transcription factor for myelination during development, is also required for myelin repair. Endogenous oligodendrocyte precursor cells (OPCs) normally produce new oligodendrocytes which regenerate myelin in response to damage. However, when myrf is removed from OPCs, mice are unable to generate new myelin. Demyelinated lesions in these mice mimic chronically demyelinated lesions in MS patients, where OPCs are unable to mature into new remyelinating oligodendrocytes. I am currently examining the functional and anatomical consequences of impaired remyelination in a mouse model of MS.

Awards

2013

Top poster at the 2013 Canadian Spinal Cord Injury Conference in Halifax

For Research

2013

MS Society of Canada Doctoral Trainee Award

For Research

2013

Top poster at the inaugural BC Stem and Regenerative Medicine Conference

For Research

2011

CIHR Transplant Trainee Award

For Research

2011

MS Society of Canada Doctoral Trainee Award

For Research

2011

Paralyzed Veterans of America Poster Award at the 14th International Symposium on Neural Regeneration

For Research

Last updated 3 September 2015