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People

Publications

  1. Cohen, S., S. Au, N. Panté 2011. How Viruses Access the Nucleus. BBA - Molecular Cell Research In press
  2. Au, S., S. Cohen, and N. Panté 2010. Microinjection of Xenopus laevis oocytes as a system for studying nuclear transport of viruses. Methods 51(11): 114-120
  3. Cohen, S., S. Au, and N. Panté 2009. Microinjection of Xenopus Laevis Oocytes. JoVE 24: http://www.jove.com/index/de [ Link ]
  4. Cohen, S., A.R. Behzad, J.B. Carroll, and N. Panté 2006. Parvoviral nuclear import: bypassing the host nuclear transport machinery. Journal of General Virology 87: 3209-3213
  5. Cohen, S. and N. Panté 2005. Pushing the envelope: microinjection of Minute virus of mice into Xenopus oocytes causes damage to the nuclear envelope. Journal of General Virology 86: 3242-3252

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Sarah Cohen

PhD

Email:
Lab phone: 604-822-0664
Web page: Lab Page
Research area: Cell and Developmental Biology
Supervisor: N. Pante
History: BSc (UBC)

In order to replicate successfully, many viruses must enter the nucleus of their host cell. Viruses use various strategies to accomplish this. The parvovirus Minute virus of mice (MVM) seems to gain entry to the nucleus using a novel strategy that involves disruption of the membranes surrounding the nucleus, and entry through the resulting breaks. I am using electron microscopy, combined with biochemical and genetic approaches, to further investigate the mechanisms employed by MVM to enter the host nucleus.

Last updated 27 May 2011